When one of the following apps is started while the Little Snitch Network Extension is active, macOS Big Sur 11.0.1 may freeze and restart with a kernel panic:
Wine (Windows emulator) and apps based on Wine
Plex Media Server
macports (during package list update)
- possibly others (please let us know)
The panic seems to be triggered by a broadcast message. The panic log reads like this:
These panics are a bug in kernel of the operating system and can only be fixed by Apple.
In the meantime, until Apple has fixed the problem, you may want to downgrade to Little Snitch 4.6. See this FAQ for instructions how to make Little Snitch 4.6 run on macOS Big Sur.